Brief Profile
Dr. Thejaswini Venkatesh is currently employed as an Assistant Professor at the Department of Biochemistry and Molecular Biology, Central University of Kerala (CUK), Kasargod, Kerala, India. Her (RNP Granulomics lab) lab at CUK works on the dynamics of P bodies, crosstalk of P body components with non-coding RNAs and implications of tRNA-derived fragments in breast cancer. She has finished her Master's degree from Mysore University and has completed her PhD from IISc (Indian Institute of Science), Bangalore. She has worked as a Post-Doctoral Researcher at inStem (Institute for Stem Cell Biology and Regenerative Medicine), Bangalore, and as an Assistant Professor at Nitte (deemed to be a University), Mangalore. She has received the prestigious Sakura fellowship from JST (Japanese Science and Technology, 2015), Young Scientist, and Young Women awards from Venus International Foundation. She has published more than 40 international publications and her lab is funded by DBT (1) and DST grants (3). She is an editor and reviewer in International Journals. She has nearly 35 peer-reviewed abstracts published in National and international symposiums and conferences. She has research collaborations with the National Institute of Technology, Calicut; KS Hegde Hospital, Mangalore; AJ Hospital Mangalore and the University of Tokhushima, Japan. She has guided 27 MSc students, 6 interns and has 5 PhD/JRF students.
Recent and Major Publications
- Suresh Padmanaban, Sanu Thankachan, Thejaswini Venkatesh,"Landscape of Clinically Relevant Exosomal tRNA-Derived Non-coding RNAs",Mol Biotech,ahead of print
- IsaacCherian, Varsha Premarajan, BarguAnitha, Ashifa Nizam, Darshan Girish, Ajay Kumar, Padmanaban S Suresh, Thejaswini Venkatesh,"In silico identification of rice and human miRNAs sequences within tRFs of O. sativa and expression analysis of rice tRFs with their corresponding miRNAs",South African Journal of Botany,ahead of print
- 1. Bhardwaj, B. K., Thankachan, S., Magesh, P., Venkatesh, T., Tsutsumi, R., & Suresh, P. S,"Current Update on Nanotechnology-Based Approaches in Ovarian Cancer Therapy.",Reprod Sci,AHEAD OF PRINT
- Shetty A, Venkatesh T, Kabbekodu SP, Tsutsumi R, Suresh PS,"LncRNA-miRNA-mRNA regulatory axes in endometrial cancer: a comprehensive overview.",Arch Gynecol Obstet.,online ahead of print
- Anoop Kallingal, Sanu Thankachan, Thejaswini Venkatesh , Shama Prasada Kabbekodu, Padmanaban S.Suresh,"Role of miR-15b/16–2 cluster network in endometrial cancer: An in silico pathway and prognostic analysis",Meta Gene,ahead of print
- Hussain SA, Deepak KV, Nanjappa DP, Sherigar V, Nandan N, Suresh PS, Venkatesh T.,"Comparative expression analysis of tRF-3001a and tRF-1003 with corresponding miRNAs (miR-1260a and miR-4521) and their network analysis with breast cancer biomarkers.",Mol Biol Reports,48(11):7313-7324
- Magesh P, Thankachan S, Venkatesh T, Suresh PS.,"Breast cancer fibroblasts and cross-talk.",Clin Chim Acta.,521:158-169
- Hussain SA, Deepak KV, Nanjappa DP, Sherigar V, Nandan N, Suresh PS, Venkatesh T.,"Comparative expression analysis of tRF-3001a and tRF-1003 with corresponding miRNAs (miR-1260a and miR-4521) and their network analysis with breast cancer biomarkers",Mol Biol Reports,48(11):7313-7324
- Thankachan S, Bhardwaj BK, Venkatesh T, Suresh PS,"Long Non-coding RNA NEAT1 as an Emerging Biomarker in Breast and Gynecologic Cancers: a Systematic Overview.",Reprod Sci,28(9):2436-2447
- Thankachan S, Bhardwaj BK, Venkatesh T, Suresh PS.,"Long Non-coding RNA NEAT1 as an Emerging Biomarker in Breast and Gynecologic Cancers: a Systematic Overview.",Reprod Sci.,28(9):2436-2447
- ," Regulation of processing bodies: From viruses to cancer epigenetic machinery. ",Cell Biology International,2020 Dec 15
- ,"Deciphering piRNA biogenesis through cytoplasmic granules, mitochondria and exosomes. ",Arch Biochem Biophys., 2020 Sep 22:108597
- ,"Liquid biopsy in ovarian cancer. ",Clin Chim Acta. ,2020 Nov;510:28-34
- ,"In silico prediction of UCLH1 disease-causing SNPs and its effects on protein stability. ",Gene Reports. ,2020 Apr 14:100677
- ,"In silico analysis of COSMIC retrieved P body gene mutations in breast cancer. ",Gene Reports. ,2020 Jun 1;19:100617
- ,"Gene expression changes and promoter methylation with the combined effects of estradiol and leptin in uterine tissue of the ovariectomized mice model of menopause. ",Mol Biol Rep., 2020 Jan;47(1):151-168
- ,"Regulated expression of Gemin5, Xrn1, Cpeb and Stau1 in the uterus and ovaries after superovulation and the effect of exogenous estradiol and leptin in rodents. ",Mol Biol Rep,,2019; 46(2), 2533-2540
- ,"Increased virulence in Pseudomonas aeruginosa at pathological glucose levels. I",nfect Dis (Lond), ,2018;5,1-4
- ,"PTPH1 immunohistochemical expression and promoter methylation in breast cancer patients from India: A retrospective study. ",J Cell Physiol, ,2019; 234(2), 1071-1079
- ,"YBX1 at the crossroads of non-coding transcriptome, exosomal, and cytoplasmic granular signaling. ",Eur J Cell Biol, ,2018;97(3),163-167
- ,"A tale of three RNAs in mitochondria: tRNA, tRNA derived fragments and mitomiRs. ",Journal of theoretical Biology, ,2017: 435;42-49
- ,"Exploration of acute genotoxic effects and antigenotoxic potential of gambogic acid using Allium cepa assay. ",Plant Physiology and Biochemistry,, 2017: 118; 643-652
- ,"Next-generation sequencing for endocrine cancers: Recent advances and challenges. ",Tumour Biol. ,2017 ;39:1010428317698376
- ,"In silico analysis of polymorphisms in microRNAs that target genes affecting aerobic glycolysis. ",Ann Transl Med. ,2016;4:69
- ,"Mining of single nucleotide polymorphisms in the 3' untranslated region of liver cancer-implicated miR-122 target genes",Ann Transl Med., 2016 ;4:102
- ,"tRFs: miRNAs in disguise. ",Gene ,2016; 579:133-138
- ,"Non-codng RNAs: Functions and application in endocrine-related cancer. ",Molecular and cellular endocrinology ,2015. 416:88-96
- ,"HER2 and uPAR cooperativity contribute to metastatic phenotype of HER2-positive breast cancer. ",Oncoscience ,2015; 2: 207-224
- ,"New insights into genetics of infertility. ",The Application of Clinical Genetics. ,2015; 8: 1–9.
- ,"Emerging roles of MCPH1: Expedition from primary microcephaly to cancer. ",European Journal of Cell Biology. ,2014; 93: 98-
- ,"Gene therapy in endocrine cancers. ",Endocrine J. ,2014; 61:655-665
- ,"Exploration of deleterious single nucleotide polymorphisms in the components of human P bodies: An insilico approach.", Gene. ,2013; 528: 360-363
- ,"Primary microcephaly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma. ",PLOS ONE. , 2013; 8:e54643
- ,"Single nucleotide polymorphisms in genes that are common targets of luteotropin and luteolysin in primate corpus luteum: Computational exploration. ",Gene. ,2012; 511: 353-357
- ,"Computational interrogation of cis-regulatory elements of genes that are common targets of luteotropin and luteolysin in the primate corpus luteum. Gene. 2012; 515: 403-409 ",Gene. ,2012; 515: 403-409
- ,"Factors associated with 2009 pandemic influenza A (H1N1) vaccination acceptance among university students from India during the post-pandemic phase. ",BMC infectious diseases. ,2011; 11: 205
- ,"Psychosocial determinants of 2009 pandemic influenza A (H1N1) vaccine acceptability among Indian health-care workers during the post-pandemic phase. ",J of infection.,2012; 65 :90-93
- ,"Molecular pathology and therapy of Endometriosis: revisited. ",Androl Gynecol: Curr Res ,2013, 1: 3
Research Projects Undertaken
Identification and analysis of tRNA derived fragments (tRFs) from rice (black, brown, red and white) derived exosome-like edible nanovesicles (ELN) for cancer therapeutics
DST-SERB
Analysis of miRNA/tRF generation from tRNAs and examination of thier sorting into exosomes and P bodies
DST
Expression analysis of PTPH1 targeting miRNAs and their crosstalk with HER2-UPAR cooperativity in breast cancer
Nitte (deemed to be University)
Reserach fund, Nitte University
Promoter methylation of P body gene components and study of its implications on P body dynamics and tRF-miR pool binding in ER dependent breast cancer
DBT
Exploratioin of diagnostic potential of non-coding RNAs-phosphatase-Her2-UPAR crosstalk in breast cancer
DBT
Identification and functional analysis of tRNA derived fragments in breast cancer
DST SERB
Miscellaneous
| Membership/Fellowship of other institutions/professionals societies : |
Life time members:
1. Indian association of cancer research
2. Society of biological chemists
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| Student related co-curricular, extension and field based activities and counseling. |
She has nearly 30 abstarcts published in National, International symposiums and conferences. She has research collaborations with NIT, Calicut; KS Hegde Hospital, Mangalore; AJ hospital Mangalore and University of Tokhushima, Japan. She has guided 27 MSc stidents and has 2 PhD students.
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| Contribution to corporate sector-management of the department and institution through participation in academic and administration,committees and responsibilities.
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Conferences organized
1. Organized 4th annual meeting of Society of Biological Chemist (Coastal Karnataka Chapter) in Nov 2015 as Scientific Secretary at Nitte University, Mangalore.
2. Conducted workshop on Female reproductive health at Dept of Biochemistry and Molecular biology on 22nd July at Central University of Kerala
3. Moderated a webinar on Real-time PCR: Fundamentals, Chemistries and Applications on 17th June 2020, Central University of Kerala.
4. Organised a webinar on- Inflammatory mechanisms mediating tumor-lymphatic crosstalk and role in cancer progression and lymph node metastasis ‘ by Dr. Sanjukta Chakraborty, University of Texas on 9th Sept, 2020 at Central University of Kerala.
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| Other activities/Responsibilities : |
Academic Presentation:
• Delivered a talk on ‘MCPH1 acts as a tumor suppressor in OSCC’ at NUS-VIT symposium, VIT, India, July 2017.
• Delivered a talk on ‘Analysis of PTPH1 targeting miRNAs as potential biomarkers in breast cancer’ at National Conference on Genetics of Human Diseases, Central University of Kerala, India, Nov 2016.
• Delivered a talk on ‘Tumor suppressors as cancer therapeutic targets: A tale of MCPH1 in oral cancer’ at National workshop “Emerging targets and biomarkers in cancer therapy” in Mangalore University, May 2016.
• Delivered a talk on ‘Primary microcepahly gene MCPH1 shows signatures of tumor suppressors and is regulated by miR-27a in oral squamous cell carcinoma’ at University of Tokushima, Tokushima, Japan, July 2015.
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| Any other relevant information, if not given above : |
In editorial board of following journals:
1. Annals of cancer science ans surgical oncology
2. SF Journal of biotechnology and biomedical engineering
3. SRL oncology and hematology
4. J of Biology for Today’s world
Reviewer in :
1. Gene, J of Genomics, Gene Reports (Elsevier)
2. Nucleic Acid research
3. Journal of experimental and clinical cancer research (BMC journal)
Alumni students who performed project in my lab are placed in IISERs, JNU, RGCB, Scientific officer (Government of Kerala).
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Teaching & Research Guidance
- Biomedical sciences:Under Graduate
- molecular biology, biomedical sciences, biochemistry, epigenetics, cancer genetics, RNA biology, Bio analytical techniques, cell biology, microbiology, molecular diagnostics, clinical biochemistry:Post Graduate
- cancer biology, genetics, non coding RNA biology, plant transcriptomics, Cytoplasmic granules,:Research Guidance