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 Central University of Kerala
02 April 2025

Dr. V.B. Sameer Kumar

Angiogenesis and Non Coding RNA Lab


Brief Profile

Dr. V.B. Sameer Kumar did his graduation and post-graduation in Biochemistry from the University of Kerala with a rank. He obtained his research degrees of M.Phil. and Ph.D. in Biochemistry from the University of Kerala and moved in to the Weizmann Institute of Sciences, Israel, for his post-doctoral research. After completing his project in WIS, he moved to Cincinnati Children’s hospital medical Centre, USA to pursue his second post-doctoral tenure, before he joined as a faculty in the Central University of Kerala. He is also instrumental in designing the course work and curriculum of biochemistry and molecular biology in Universities across Kerala being a member of the board of studies of a couple of Universities and Academic council member of CUK. He holds the portfolios of the Assistant Registrar Purchase, Assistant Registrar Legal, Member Secretary of Institutional Biosafety council of the Central University of Kerala, Quality Assessor, COVID-19 testing lab to mention some.

He specializes in the areas of Tumor biology, Endothelial cell biology, angiogenesis and functional analysis of non-coding RNA.  He runs multiple projects totaling a tune of approximately 1.5 Crores in his lab funded by DST, DBT and KSCSTE, which are related to elucidating the role of miRNA in anti-cancer drug resistance and tumor angiogenesis. Work in his lab also focuses on the metabolic regulation of angiogenesis and various aspects of endothelial cell behavior. He has published more than 50 research articles in peer reviewed international journals and books of repute like Nature communications, IJBCB, JCP, JCB, Cells etc. and has presented his work at several National and International Conferences many of which were recognized with an award. His lab is working in collaboration with scientists at the Central Leather Research Institute, Indian Institute of Science and University of Kerala.  4 students have completed PhD, one submitted thesis recently and now 3 students are working for PhD under his guidance. He has successfully guided more than 30 M.Sc. dissertations and 4 M.Phil. dissertations.   In recognition of his contributions to the field of science research and teaching, he was conferred the fellowship of the Kerala Academy of Science, by the Hon’ble Governor of Kerala, Justice P. Satashivam in 2018. Further his research has been collated in the BBA raising Star series, which highlights the research, that has the potential to change the course of biological research in the coming decade.

47

Publications

5

Projects

10

Students

3

Courses Taught


...
Dr. V.B. Sameer Kumar
Professor
Department of Genomic Science
  0467-2309344
  [email protected]
  Personal Website
  Vidwan Profile
Academic Identity
 Google Scholar ID
 ORCID
 Scopus ID
 Researcher ID

 Research

None

 Recent and Major Publications

  1. Kumar VBS, Anjali K,"Tumour generated exosomal miRNAs: A major player in tumour angiogenesis",BBA. Molecular basis of disease,1868(6):166383

  2. Vijayakumar Sheela Haritha,Mohan Manuraj,Dr. Thekke Veedu Sruthi,Dr. V. B. Sameer Kumar,Dr. Santhakumari Amma Ravindran Nair Sarath Kumar,Dr. Sarojini Sharath Shankar,Dr. Raghavan Baby Rakhi,"3D-Architectured MoS2-Microflower-Modified Electrodes toward Electrochemical Determination of Imidacloprid",ChemistrySelect,7-

  3. K.Anjali and V.B. Sameer Kumar,"2-Deoxy glucose for COVID-19 treatment needs cautious handling",Current Science,121 No. 9,

  4. Rajendran Satheeshkumar, Lincy Edatt, Aathi Muthusankar, VB Sameer Kumar, Karnam Jayarampillai Rajendra Prasad,"Synthesis of Novel Quin[1,2-b]Acridines: In Vitro Cytotoxicity and Molecular Docking Studies",Polycyclic Aromatic Compounds,1631-1645

  5. Raji, Grace & Poyyakkara, Aswini & Krishnan, Anjali & Maurya, Ashutosh & Changmai, Udeshna & S, Sharath & Kumar, Sameer.,"Horizontal Transfer of miR‐643 from Cisplatin‐Resistant Cells Confers chemoresistance to Recipient Drug‐Sensitive Cells by Targeting APOL6",Cells,10;1341

  6. K Arunkumar, Rathinam Raja, VB Sameer Kumar, Ashna Joseph, T Shilpa, Isabel S Carvalho,"Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds",Journal of Food Measurement and Characterization,567-576

  7. Levna Chacko, Aswini Poyyakkara, VB Sameer Kumar, PM Aneesh,"MoS2, a new perspective beyond graphene",Fundamentals and Properties of Multifunctional Nanomaterials,499-541

  8. A Poyyakkara, S Thekkeveedu, SS Shankar, VBS Kumar,"Regulation of Angiogenesis Using Nanomaterial Based Formulations: An Emerging Therapeutic Strategy to Manage Multiple Pathological Conditions",Theranostics-An Old Concept in New Clothing,275

  9. Saranya Kothaplamoottil Sivan, Sarojini Sharath Shankar, Akshaykumar Kandambath Padinjareveetil, Rajendra Pilankatta, VB Sameer Kumar, Beena Mathew, Bini George, Pooyan Makvandi, Miroslav Černík, Vinod VT Padil, Rajender S Varma,"Fabrication of a Greener TiO2@Gum Arabic-Carbon Paste Electrode for the Electrochemical Detection of Pb2+ Ions in Plastic Toys",ACS omega,25390-25399

  10. Arunkumar, K., Raja, R., Kumar, V.B.S. et al,"Antioxidant and cytotoxic activities of sulfated polysaccharides from five different edible seaweeds",Journal of Food Measurement and Characterization,15, pages567–576

  11. P. Aswini, Anjali Kunhi Krishnan and V. B. Sameer Kumar,"Micro-RNA Mediated Signalling Circuits in Endocrine-Dependent Malignancies of Human Reproductive System",Journal of Endocrinology and Reproduction,Vol 24(1), 01-19

  12. Haritha Kunhiraman, Vishnu Ramachandran, Lincy Edatt and V.B. Sameer Kumar,"Regulation of poly ADP ribosylation of VEGF by an interplay between PARP-16 and TNKS-2",Molecular and Cellular Biochemistry,471(1-2):15-27

  13. Lincy Edatt, Aswini Poyyakkara, Grace R. Raji, Vishnu Ramachandran, S. Sharath Shankar and V. B. Sameer Kumar,"Role of Sirtuins in Tumor Angiogenesis",Frontiers in oncology,9, 1516

  14. Shankar S.S., Ramachandran V., Raj R.P., Sruthi T.V., Kumar V.B.S.,"Carbon Quantum Dots: A Potential Candidate for Diagnostic and Therapeutic Application",Nanobiomaterial Engineering,49-70

  15. K Soumya, Karickal R Haridas, Jesna James, V B Sameer Kumar, Lincy Edatt, S Sudheesh,"Study of In vitro antioxidant and DNA damage protection activity of a novel luteolin derivative isolated from Terminalia chebula",Journal of Taibah University for Science,13; 755-763

  16. S. Sharath Shankar, Rayamarakkar M. Shereema, Vishnu Ramachandran, T. V. Sruthi, V. B. Sameer Kumar, R. B. Rakhi,"Carbon Quantum Dot-Modified Carbon Paste Electrode-Based Sensor for Selective and Sensitive Determination of Adrenaline",ACS Omega,4, 7903-7910

  17. Rayammarakkar M., Shereema Talasila Prasada Rao, V B Sameer Kumar, Sharath Shankar S,"Individual and simultaneous electrochemical determination of metanil yellow and curcumin on carbon quantum dots based glassy carbon electrode",Materials Science and Engineering C-Materials for Biological Applications,93:21-27

  18. Emmanuel Simon, Aswini Poyyakkara, V.B. Sameer Kumar, Gokuldas Mankadath,"Curcumin and its synthetic analogue dimethoxycurcumin differentially modulates antioxidant status of normal human peripheral blood mononuclear cells",Free radical research.,52(5):583-591

  19. Kumar VB, Viji RI, Kiran MS &Sudhakaran PR,"Modulation of expression of LDH isoenzymes in endothelial cells by laminin: Implications for angiogenesis",Journal of cellular biochemistry,103, 1808-1825

  20. TV Sruthi, Lincy Edatt, Grace R Raji, Haritha Kunhiraman, Sharath S Shankar, Vandana Shankar, Vishnu Ramachandran, Aswini Poyyakkara, Sameer VB Kumar,"Horizontal transfer of miR‐23a from hypoxic tumor cell colonies can induce angiogenesis",Journal of cellular physiology,233, 3498-3514

  21. Chacko, L., Poyyakkara, A., Kumar, V.B.S., Aneesh, P.M,"MoS2-ZnO nanocomposites as highly functional agents for anti-angiogenic and anti-cancer theranostics",Journal of Materials Chemistry B,6(19), pp. 3048-3057

  22. P. Ajithkumar, M. P. Yashoda, S. Prasannakumar, T. V. Sruthi &V. B. Sameer Kumar,"Synthesis, characterization, microstructure determination, thermal studies of poly (N-vinylpyrrolidone-maleic anhydride-methyl methacrylate)",Journal of Macromolecular Science, Part A,55:4, 362-368

  23. Rajendran Satheeshkumar, Aathi Muthusankar, Lincy Edatt, V. B. Sameer Kumar, Hazel A. Sparkes & Karnam Jayarampillai Rajendra Prasad,"Synthesis of heteroannulated cyclopent[ b ]indoles: Exploration of in vitro cytotoxicity and molecular docking studies;",Synthetic communications,48(4):1-15

  24. Grace R. Raji, Sruthi T.V., Lincy Edatt, Haritha K., S. Sharath Shankar and V.B. Sameer Kumar,"Horizontal transfer of miR-106a/b from cisplatin resistant hepatocarcinoma cells can alter the sensitivity of cervical cancer cells to cisplatin",Cellular Signalling,38:146-158

  25. M. P. Ajithkumar, M. P. Yashoda, S. Prasannakumar, T. V. Sruth&V. B. Sameer Kumar,"Poly(N-vinyl-2-pyrrolidone-maleic anhydride-styrene) grafted terpolymer: Synthesis, characterization, and bactericidal property evaluation against E. coli and S. epidermidis",Journal of Macromolecular Science, Part A,54:7, 480-488

  26. Lincy E., Ashutosh K.M., Grace R., Haritha K., and V.B. Sameer Kumar,"MicroRNA 106a regulates Matrix Metalloprotease9 in a Sirtuin-1 Dependent Mechanism",Journal of Cellular Physiology,233(1):238-248

  27. Sateeshkumar R., Edatt L., Kumar VBS and Prasad RJK,"A Facile Regioselective Synthesis of New Class of Cyclopent [b] indole dispiro heterocycles via1, 3‐Dipolar Cycloaddition protocol and in vitro Cytotoxic studies",ChemistrySelect,2(9):2626-2633

  28. Lincy E., Haritha K., Sruthi T. V., Aswini P., and V.B. Sameer Kumar,"2-Deoxy glucose regulates MMP-9 in a SIRT-1 dependent and NFKB independent Mechanism",Molecular and cellular biochemistry,423(1-2):197-206

  29. Haritha K., Lincy E., Sruthi T. V., Aswini P., Viji R. I., Kiran M.S., Sudhakaran P.R. and V.B. Sameer Kumar,"2-Deoxy Glucose Modulates Expression and Biological Activity of VEGF in a SIRT-1 Dependent Mechanism",Journal of cellular Biochemistry.,118(2):252-262

  30. Haritha K., Lincy E. and V.B. Sameer Kumar,"2 Deoxy Glucose reduces angiogenic and metastatic potency of tumor cells",Journal of cellular biochemistry.,118(2):252-262

  31. Sebastian J Midhun, DamodaranArun, LincyEdatt, MV Sruthi, VV Thushara, Oommen V Oommen, V B Sameer Kumar,LekhaDivya,"Modulation of digestive enzymes, GH, IGF-1 and IGF-2 genes in the teleost, Tilapia (Oreochromismossambicus) by dietary curcumin",Aquaculture International,24, 1277–1286

  32. RM Shereema, TV Sruthi, VBS Kumar, TP Rao, SS Shanka,"Angiogenic profiling of synthesized carbon quantum dots",Biochemistry,54 (41), 6352-6356

  33. V. B. Sameer Kumar, S. Binu, S. J. Soumya, Haritha K. & P. R. Sudhakaran,"Regulation of vascular endothelial growth factor by metabolic context of the cell",Glycoconjugate journal,31(6-7):427-34

  34. Shabnam Pooya, Xiaona Liu, VB Sameer Kumar, Jane Anderson, Fumiyasu Imai, Wujuan Zhang, Georgianne Ciraolo, Nancy Ratner, Kenneth DR Setchell, Yutaka Yoshida, Michael P Jankowski, Biplab Dasgupta,"The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism",Nature communications,Article number: 4993 (2014)

  35. Sameer Kumar VB, Viji RI, Kiran MS &Sudhakaran,"Angiogenic response of Endothelial Cells to Fibronectin. Biochemical Role of Cell Surface Macromolecules",Advances in Experimental Medicine and Biology,749, 131-151

  36. Binu S, Soumya SJ, Kumar VB &Sudhakaran PR,"Poly-ADP-ribosylation of vascular endothelial growth factor and its implications on angiogenesis",Advances in Experimental Medicine and Biology,749:269-78

  37. Xiaona Liu, V B Sameer Kumar, Christopher M Mcpherson, Lionel Chow, AdyKendler, iplabDasgupta,"Active AMP Kinase Is An Integral Part Of High-grade Glioma That Can Synergize With Mtor For Glioma Growth, Survival, And Metabolic Control",Neuro-oncology,13; iii69–iii72

  38. Kumar VB, Viji RI, Kiran MS &Sudhakaran PR,"Angiogenic Effect of Laminin Involves Modulation of Cyclooxygenase-2 and Prostaglandin Levels",Experimental biology and medicine (Maywood, N.J.),236(1), 44–51.

  39. Kumar VB, Viji RI, Kiran MS &Sudhakaran PR,"Negative Modulation of eNOS by Laminin Involving Post-translational Phosphorylation",Journal of cellular physiology,219, 123-131

  40. Viji RI, Kumar VB, Kiran MS &Sudhakaran PR,"Modulation of endothelial nitric oxide synthase by fibronectin",Molecular and Cellular Biochemistry,323, 91-100

  41. Sudhakaran PR, Viji RI, Kiran MS &Sameer Kumar VB,"Endothelial Cell - Laminin Interaction: Modulation of LDH Expression Involves α6β4 Integrin- FAK-p38MAPK Pathway",Glycoconjugate journal,26, 697-704

  42. Viji RI, Kumar VB, Kiran MS &Sudhakaran PR,"Modulation of cyclooxygenase in endothelial cells by fibronectin: Relevance to angiogenesis",Journal of cellular biochemistry,105(1):158-66

  43. MS Kiran, RI Viji, VB Sameer Kumar, PR Sudhakaran,"Modulation of angiogenic factors by ursolic acid",Biochemical and biophysical research communications,371,556-560

  44. Viji RI, Kumar VB, Kiran MS &Sudhakaran PR,"Angiogenic response of endothelial cells to heparin binding domain of fibronectin",The International Journal of Biochemistry & Cell Biology,40, 215-226

  45. M.S. Kiran,V.B. Sameer Kumar,R.I. Viji,G.T. Sherin,K.N. Rajasekharan,P.R. Sudhakaran,"Opposing effects of curcuminoids on serum stimulated and unstimulated angiogenic response",Journal of cellular physiology,215, 251-264

  46. VBS Kumar, RI Viji, MS Kiran, PR Sudhakaran,"Endothelial cell response to lactate: implication of PAR modification of VEGF",Journal of cellular physiology,211, 477-485

  47. Kiran MS, Sameer Kumar VB, Viji RI & Sudhakaran P. R.,"Temporal relationship between MMP production and angiogenic process in HUVECs",Cell biology international,30,704-713


 Group Members

 Research Projects Undertaken

Analysis of the role of miRNAs in the process of Endothelial Mesenchymal transition during Angiogenesis

 DST SERB

DST SERB FAST TRACK

Functional analysis of putative host miRNA binding sites in the SARS-CoV-2 genome and viral derived miRNAs targeting host gene expression: Implications on thrombosis and endothelial dysfunction

 ICMR

ICMR DHR

Profiling miRNA downstream a6B4 integrin: A strategy tp target angiogenesis

 DBT

DBT Pilot Project

Identification and functional analysis of tumor generated exosomal miRNA and elucidating its role in anti cancer drug resistance

 KSCSTE

KSCSTE

Understanding the role of unique miRNA mediated signalling circuits recruited differentially during endothelial mesenchymal transition associated with fibrosis and angiogenesis

 DST SERB

DST SERB CRG

 Books / Chapters

  • Chapter(s) - Co-Author, (2021). Theranostics-An Old Concept in New Clothing, IntechOpen, Vienna, Austria, 978-1-83962-788-0

    •  Patents

      None

     Miscellaneous

     Membership/Fellowship of other institutions/professionals societies : 
    Fellow of Kerala Academy of Science
Chairman, Society of Young Scientist's-Central University of Kerala
Coordinator of the Innovation Club of the university and Institutional Innovation Council
Member Secretary, IBSC (Institutional Biosafety committee)
Board of studies member, Biochemistry of Calicut University
Chairman Board of studies, Molecular Biology- Calicut University
General convener of Cluster Seminar on “Biology to New Biology: he Paradigm Shift, April 10 -12, 2012
Organizing secretary, Workshop on Research Methodology- as part of Swasraya Bharat, Oct 17, 2014
Organizing secretary, Workshop on Decoding the Non-coding, 15-21 Feb 2016
Has contributed significantly to the corporate life of the CU Kerala as member ofseveral committees.
As part of extension activity has involved in training school students through different programs
Diploma in Computer Management by ER&DCI
Co-Ordinator, District level Innovation Fest 2019
 Represented CUK at Rashtrapati Bhavan, for Fe
     Student related co-curricular, extension and field based activities and counseling.
     Contribution to corporate sector-management of the department and institution through participation in academic and administration,committees and responsibilities.
     Other activities/Responsibilities :
     Any other relevant information, if not given above :

     Contact

    Full Name
    		 Dr. V.B. Sameer Kumar
    Address
    		 Room No 317, Krishna Building, Central University of Kerala Thejaswini Hills, Periya PO, Kasaragod
    Telphone Number
    (With STD Code)
    		 0467-2309344
    PinCode
    		 697320

     Teaching & Research Guidance

    • Cell Biology, Molecular Biology, Genetic Engineering, Endocrinology, Analytical Biochemistry:Post Graduate
    • Angiogenesis & Functional Analysis of Non-Coding RNA:Research Guidance
    • Workshop on Decoding the Non-Coding:Short term/Continuing Education/Specialist Courses conducted