Brief Profile
Professor & Head, Department of Chemistry, Central University of Kerala (Since July 2023)
Professor, Department of Chemistry, Central University of Kerala (Since Sep 2022)
Chief Vigilance Officer, Central University of Kerala (Mar-Jun 2024)
Director, Research & Development Cell, Central University of Kerala (Jan - Oct 2023)
Assistant Professor, Department of Physical Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai-625021 (Apr 2010 - Aug 2022)
Post-doctoral Research Fellow, Institute of Organic Chemistry and Chemical Biology, & Center for Biomolecular Magnetic Resonance (BMRZ), J.W. Goethe University-Frankfurt am Main, Germany (Dec 2007 – Mar 2010) Mentor: Prof. Dr. Harald Schwalbe
Post-doctoral Research Fellow, Division of Structural and Computational Biology, School of Biological Sciences, Nanyang Technological University, Singapore (Sep 2005 – Nov 2007) Mentor: Prof. Dr. Jaume Torres
Ph.D, Molecular Biophysics Unit, Indian Institute of Science, Bangalore. (Jul 2005)
Research Supervisor: Prof. Dr. P. Balaram
Recent and Major Publications
- Murugesan Ponmagaram, Krishnan Saranraj and Karuppiah Muruga Poopathi Raja*,"Methyl 3-[(tert-butoxycarbonyl)amino]benzoate",IUCrData,10, x250542
- Sithanantham Muneeswaran, and Karuppiah Muruga Poopathi Raja*,"Modes of binding of small molecules dictate the interruption of RBD-ACE2 complex of SARS-CoV-2",ChemPhysChem,26, e202400751
- Krishnan Saranraj, and Karuppiah Muruga Poopathi Raja*,"Microwave-Assisted Synthesis of Peptidomimetic trans-Delta-Aminopent-3-enoic Acid and Derivatives",New Journal of Chemistry,48, 16620-1663
- Rajamanikkam Kamaraj, Subhrojyoti Ghosh, Souvadra Das, Shinjini Sen, Priyanka Kumar, Madhurima Majumdar, Renesa Dasgupta, Sampurna Mukherjee, Shrimanti Das, Indrilla Ghose, Petr Pavek, Muruga Poopathi Raja Karuppiah, Anil A. Chuturgoon, and Krishnan Anand,"Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions",Bioconjugate Chemistry,35 (8), 1089-1115
- Cheemala Ashok, Murugan Selvam, Saravanaraman Ponne, Phani K. Parcha, Karuppiah Muruga Poopathi Raja and Sudhakar Baluchamy,"CREB acts as a common transcription factor for major epigenetic repressors; DNMT3B, EZH2, CUL4B and E2F6",Medical Oncology,37, 68
- Rajkumar Misra, K. Muruga Poopathi Raja, Hans-Jörg Hofmann and Hosahudya N. Gopi,"Modulating the Structural Properties of α,γ-Hybrid Peptides by α-Amino Acid Residues: Uniform 12-Helix Versus “Mixed” 12/10-Helix",Chemistry - A European Journal,23, 16644-52
- Rajkumar Misra, Abhijith Saseendran, Gijo George, Kuruva Veeresh, K. Muruga Poopathi Raja, Srinivasarao Raghothama, Hans-Jörg Hofmann and Hosahudya N. Gopi,"Structural Dimorphism of Achiral α,γ-Hybrid Peptide Foldamers: Coexistence of 12- and 15/17-Helices",Chemistry - A European Journal,23, 3764-72
- Mothukuri Ganesh Kumar, Varsha J. Thombare, Mona M.Katariya, KuruvaVeeresh, K. Muruga Poopathi Raja and Hosahudya N. Gopi,"Non-classical Helices with Backbone cis Carbon-Carbon Double Bonds: Structural Features of alpha, gamma-Hybrid Peptide Foldamers",Angewandte Chemie International Edition,55, 7847-51
- Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Bristle, Philip Koch, Christian Haass, Amedeo Caflisch and Lawrence Rajendran,"Specific inhibition of -secretase processing of the Alzheimer’s disease Amyloid Precursor Protein",Cell Reports,14, 2127-2141
- Mothukuri Ganesh Kumar, Sushil N. Benke, K. Muruga Poopathi Raja* and Hosahudya N. Gopi*,"Engineering polypeptide folding through trans double bonds: transformation of miniature -meanders to hybrid helices",Chemical Communications,51, 13397-13399
- Mothukuri Ganesh Kumar, Sachitanand M. Mali, K. Muruga Poopathi Raja and Hosahudya N. Gopi,"Design of Stable beta-Hairpin Mimetics through Backbone Disulfide Bonds",Organic Letters,17, 230-233
- Anupam Bandyopadhyay, Sachitanand M. Mali, Pooja Lunawat, K. Muruga Poopathi Raja and Hosahudya N. Gopi,"Synthesis and Structural Investigations of Functionalizable Hybrid beta-Hairpin",Organic Letters,13, 4482-4485
- Reza Dastvan, Bela E. Bode, Muruga Poopathi Raja Karuppiah, Andriy Marko, Sevdalina Lyubenova, Harald Schwalbe and Thomas Prisner,"Optimization of Transversal Relaxation of Nitroxides for PELDOR Spectroscopy in Phospholipid Membranes",The Journal of Physical Chemistry B,114, 13507-13516
- Reza Dastvan, Bela E. Bode, Muruga Poopathi Raja Karuppiah, Andriy Marko, Sevdalina Lyubenova, Harald Schwalbe and Thomas Prisner,"Optimization of Transversal Relaxation of Nitroxides for PELDOR Spectroscopy in Phospholipid Membranes",The Journal of Physical Chemistry B,114, 13507-13516
- Anindita Sengupta, S. Aravinda, N. Shamala, K. Muruga Poopathi Raja and P. Balaram,"Structural studies of model peptides containing beta-, gamma- and delta-amino acids",Organic & Biomolecular Chemistry,4, 4214-4222.
- K. Ananda, Prema G. Vasudev, Anindita Sengupta, K. Muruga Poopathi Raja, N. Shamala and P. Balaram,"Polypeptide Helices in Hybrid Peptide Sequences",Journal of American Chemical Society,127, 16668-16674
- K. Ananda, S. Aravinda, P. G. Vasudev, K. Muruga Poopathi Raja, H. Sivaramakrishnan, K. Nagarajan, N. Shamala and P. Balaram,"Solid state conformations and solution equilibria",Current Science,85, 1002-1011
- E. Y. Cheung, E. E. McCabe, K. D. M. Harris, R. L. Johnston, E. Tedesco, K. Muruga Poopathi Raja, and P. Balaram,"C-H•••O Hydrogen Bond Mediated Chain Reversal in a Peptide Containing a gamma-Amino Acid Residue, Determined Directly from Powder X-ray Diffraction Data",Angewandte Chemie International Edition,41, 494-496
- E. Tedesco, K. D. M. Harris, R. L. Johnston, G. W. Turner, K. Muruga Poopathi Raja and P. Balaram,"Ab initio structure determination of a peptide beta-turn from powder X-ray diffraction data",Chemical Communications,1460-1461
Research Projects Undertaken
National Network Project of Tamil Nadu Agricultural University, Coimbatore-[40237]
Department of Biotechnology
Design, Synthesis and Evaluation of Potential Peptidomimic Inhibitors for β-Secretase (BACE1) Enzyme of Neurodegenerative Alzheimer’s Disease
SERB
Poly-Glutamine Peptides Aggregation of Neurodegenerative Spinocerebellar Ataxias: Mechanistic Investigation towards Developing Inhibitors
SERB
Development and Evaluation of Anti-Viral Peptidomemitics to Combat SARS-CoV-2
BRNS
Design, validation, and development of novel peptidomimetic therapeutics targeting SARS-CoV-2 replication
SERB-IRHPA
Development of Anti-viral Peptide Aptamers for SARS-CoV-2: Design and Evaluation
Department of BioTechnology (Govt. of India)
Patents
- Graphene and functional graphenes in frictional materials and uses thereof, S. Venkatesh and K. Muruga Poopathi Raja, Application No : 202141003489 (Filed Date: 25 Jan, 2021)
- Cis (z) 4-t-butylgabapentin and its Synthesis. Kuppuswamy, Nagarajan; Hariharan, Sivaramakrishnan; Iyer, Venkatachalam Shankar; Balakrishnan, Suresh Babu; Krishnamurthi, Gopalakrishnan; Kuppana, Ananda; Karuppiah, Muruga Poopati Raja; Padmanabhan, Balaram; Subrayashastry, Aravinda; Prema, GouriammaVasudev; Narayanaswamy, Shamala. (Hikal Limited, India; Indian Institute of Science). European Patent Application Number: EP2172445 A1 (07 Apr, 2010)
- Gabapentin analogues and Process thereof. Kuppuswamy, Nagarajan; Hariharan, Sivaramakrishnan; Iyer, Venkatachalam Sankar; Balakrishnan, Suresh Babu; Krishnamurthi, Gopalakrishnan; Kuppanna, Ananda; Karuppiah, Muruga Poopati Raja; Padmanabhan, Balaram; Subrayashastry, Aravinda; Prema, Gouriamma Vasudev; Narayanaswamy, Shamala. (Hikal Limited, India; Indian Institute of Science). U.S. Pat. No. US7632864 B2 (Dec 15, 2009).
- 4-t-butylgabapentin and its Synthesis. Kuppuswamy, Nagarajan; Hariharan, Sivaramakrishnan; Iyer, Venkatachalam Shankar; Balakrishnan, Suresh Babu; Krishnamurthi, Gopalakrishnan; Kuppana, Ananda; Karuppiah, Muruga Poopati Raja; Padmanabhan, Balaram; Subrayashastry, Aravinda; Prema, GouriammaVasudev; Narayanaswamy, Shamala. (Hikal Limited, India; Indian Institute of Science). PCT International Publication Number: WO2005/087709 A1 (22 Sep, 2005),
Miscellaneous
| Membership/Fellowship of other institutions/professionals societies : |
Life member, National Magnetic Resonance Society, India
Life member, Indian Peptide Society, India
Life Member, Chemical Research Society of India
Life member, Association of Chemistry Teachers
Member, Royal Society of Chemistry
Member, American Chemical Society
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| Contribution to corporate sector-management of the department and institution through participation in academic and administration,committees and responsibilities.
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| Any other relevant information, if not given above : |
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